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Updated: October 2026 | Label, research and prices checked
An honest look at the energy supplement from Advanced Bionutritionals that is built around NAD and mitochondria. We read the official label, checked the research behind each ingredient, and went through the price and refund terms so you know what you are buying.
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Advanced Mitochondrial Formula is a dietary supplement in capsules, made for adults who feel low on energy as they get older. Each bottle holds 60 capsules, a 30-day supply at 2 capsules a day.
The label lists 11 active ingredients, led by niacinamide (a form of vitamin B3), D-ribose and a resveratrol extract, plus CoQ10, PQQ, acetyl L-carnitine and others.
According to the manufacturer, mitochondria are the cell’s “power plants”, and the NAD they rely on drops with age. The formula is designed to feed that system so your cells make more energy.
The research picture is more modest: the NAD and mitochondria link is real science, and some ingredients such as CoQ10 have human trials on fatigue. There is no published trial on this exact formula. We break this down in the How It Works section.
Designed for adults who feel more tired than they used to, and who want a daily capsule instead of more coffee or energy drinks.
It is not a treatment for any medical condition. Constant or unexplained fatigue deserves a check-up first. If you take prescription medication, talk to your doctor before starting.
Niacinamide, D-ribose, resveratrol, CoQ10, PQQ and six more in one serving.
No caffeine on the label, so it should not keep you up at night.
One serving a day. Easy to keep up.
All 11 amounts are printed on the Supplement Facts panel.
What makes this formula different from the typical energy supplement, and what each point is based on.
Built around cell energy, not stimulants
The maker positions the formula as a way to support the energy your cells make, instead of giving a short boost like coffee. The label has no caffeine or other stimulant listed.
200 mg niacinamide per serving
Niacinamide is a form of vitamin B3 that the body can use to make NAD. The maker says it can raise NAD by 3,000%. We found no study that backs that number for this dose, and we explain why in the How It Works section.
50 mg per serving
CoQ10 is the best studied ingredient in the formula for tiredness. A review of 13 randomized trials with 1,126 people found a small to moderate drop in fatigue scores compared with placebo.
No proprietary blend
Many energy formulas hide their amounts inside a “blend”. Here each of the 11 ingredients has its own dose on the label, so you can compare it with the studies yourself.
Two capsules a day
The maker’s directions are simple: two capsules a day. A 3-bottle order covers about 90 days.
90 days to decide
The maker offers a 90-day money-back guarantee, and orders are processed by Digistore24, a large and established online reseller. Return rules are in the Pros and Cons section.
How it compares with the common formulas on the shelf.
This formula: cell energy (NAD, CoQ10, PQQ)
Typical: caffeine, B-vitamins
Different approachThis formula: none on the label
Typical: often caffeine or guarana
✓This formula: all 11 printed
Typical: varies by brand
✓This formula: 90 days
Typical: varies by brand
✓Covered by the 90-day money-back guarantee
A breakdown of the 11 active ingredients, with the dose from the official label and the level of research behind each one.
Every serving of 2 capsules delivers 1,070 mg of active ingredients, and all 11 amounts are printed on the label. The maker highlights niacinamide, D-ribose and the resveratrol extract as the three main ones.
Vitamin B3 (1,250% of the Daily Value)
The maker’s lead ingredient, and the basis of its claim that NAD can rise by 3,000%. Human trials show that B3-type NAD precursors do raise NAD in the blood, but trials that also measured tiredness have not consistently found less fatigue than placebo. The dose also sits well above the 35 mg upper limit set for supplemental niacin, though far below the 3,000 mg a day where NIH reports liver effects.
A 5-carbon sugar
A building block of ATP, the cell’s energy molecule. Open-label studies in chronic fatigue syndrome and fibromyalgia used 5 grams three times a day, which is 60 times the amount in one serving here.
Trans-resveratrol from Polygonum cuspidatum (itadori)
The maker calls it a “sirtuin activator”. Some human trials in older adults saw better muscle mitochondria or fatigue resistance at 500 mg a day combined with exercise. A review of 155 trials found doses from 5 to 5,000 mg, with a median near 490 mg. At 25 mg this formula is far below that.
Pyrroloquinoline quinone disodium salt
The maker says it tells cells to make new mitochondria. That mechanism comes mostly from lab work. A small human study gave 20 mg a day for 8 weeks and looked at stress, fatigue and sleep. This formula has a quarter of that dose.
ALCAR
The maker says it carries fat into the mitochondria to be burned for energy. Some studies suggest benefits for mental and physical fatigue in older adults. A 2025 trial of carnitine with alpha lipoic acid for 4 weeks did not improve exercise performance.
Ubiquinone
The best studied ingredient in the formula for tiredness. A 2022 review of 13 randomized trials (1,126 people) found a small to moderate drop in fatigue scores. Effects were larger with higher daily doses and longer use, and there was some sign of publication bias.
Turmeric extract, 95% curcuminoids
The maker says it improves VO2 max within weeks. We did not find a trial that backs that for this dose. Curcumin is poorly absorbed on its own, which is why the formula pairs it with black pepper extract.
Quercetin dihydrate (Sophora japonica)
A plant flavonoid. Human research is mostly about exercise: short trials suggest faster recovery from muscle damage and better time to exhaustion in cycling. That is not the same as everyday tiredness.
R-ALA
An antioxidant the body also makes. Most human research is in diabetic nerve pain, not energy. We did not find solid evidence that this dose lifts everyday energy.
Magnesium malate (10.7% of the Daily Value)
An essential mineral. Adults need 310 to 420 mg a day, depending on age and sex, so this is a small top-up. It helps if your diet is low in magnesium, but it is not a high dose.
Black pepper extract (Piper nigrum)
Included to raise absorption. In a human study, 20 mg of piperine with 2 g of curcumin increased curcumin availability by about 2,000%. This formula has half the piperine and a much smaller curcumin dose, so the gain will differ. Piperine works by slowing the liver and gut enzymes that process some compounds, so it can also change how some medicines are handled.
What the manufacturer and the label say about how it is made, and what we could not confirm.
Secure checkout on the official website
How the formula is designed to work, side by side with what the research supports today.
The maker says
Mitochondria are the “power plants” of your cells, and making them stronger is the key to feeling younger.
The research says
Mitochondria do make most of your cell energy, and they change with age. This part is real. How much a capsule can change them in healthy adults is the open question.
The maker says
Niacinamide can raise NAD by 3,000% in 30 minutes, and NAD is half as high in your 40s as in your 20s.
The research says
Trials show NAD precursors raise NAD in blood, usually from about 60% to a few-fold. We found no study that supports a 3,000% jump from 200 mg. Trials of related compounds (NR, NMN) did not consistently reduce fatigue versus placebo.
The maker says
Eight more nutrients protect mitochondria and help the body make new ones.
The research says
CoQ10 has the strongest human data for tiredness. For resveratrol, PQQ and D-ribose, the doses in studies are higher than what is in one serving here.
The maker says
You may feel a boost in about 3 weeks, and the maker suggests trying it for at least 3 months.
The research says
Supplement trials usually run 8 to 12 weeks. Three months is a fair test and fits inside the 90-day guarantee with the 3-bottle package.
A review of 13 randomized trials with 1,126 people found a small to moderate reduction in fatigue scores compared with placebo.
Frontiers in Pharmacology, 2022
NR and NMN raise blood NAD in humans, but a 12-week NMN trial in older adults found no difference in fatigue versus placebo.
Nutrients, 2022 | review of human NAD+ booster trials
In healthy volunteers, 20 mg of piperine raised the availability of 2 g of curcumin by about 2,000%.
Shoba et al., Planta Medica, 1998
Week 1
Start The Routine
2 capsules a day, as the label directs.
Weeks 3 to 4
First Check-In
The maker says some people notice a change here. Note your energy, sleep and focus.
Weeks 8 to 12
Fair Evaluation
The usual length of supplement studies. This is when you can judge it properly.
Day 90
Guarantee Deadline
If it is not working for you, ask for your refund before this date.
This timeline is based on how supplement studies are run. It is not a promise of results.
The facts that matter before you order.
105
Customer reviews reported by the manufacturer (4.3 out of 5 average)
90 days
Money-back guarantee on every package
$66.65
Lowest price per bottle (6-bottle package)
11
Active ingredients, all with doses on the label
Payment, customer support and refunds are handled by Digistore24, a large online reseller used by thousands of product sellers.
The maker says the product is not sold in stores. Listings on marketplaces are not covered by the guarantee.
Prices are in US dollars. The maker lists free shipping on the 3 and 6 bottle packages but does not say which countries. Check the total at checkout for your country.
The sales page features Dr. Frank Shallenberger and discloses that he is paid by Advanced Bionutritionals for formulating and endorsing the product. The health markers it gives for him are not something we can verify. The customer reviews on that page are selected and shown by the maker, and the maker notes they may not reflect a typical result.
Everything you need to know about how safe it is and who should be careful.
No caffeine or other stimulant on the label.
HPMC capsule, cellulose, silica and calcium stearate.
All 11 amounts are on the Supplement Facts panel.
Designed for adults. Keep out of reach of children.
The maker lists no side effects. Based on the ingredients, these are the things to watch:
Medical consultation recommended. If you have a medical condition or take any prescription medication, talk to your doctor before starting this supplement. It is not meant to diagnose, treat, cure or prevent any disease.
An unbiased look at the advantages and disadvantages to help you decide.
Advanced Mitochondrial Formula is not “rocket fuel”, and the sales page oversells the science, especially the NAD number. What it does offer is a stimulant-free formula with every dose on the label, one well-studied ingredient in CoQ10, and a 90-day window to see how your body responds.
If you want to try it, the 3-bottle package is the sensible choice: it covers about 90 days, the same as the guarantee. The 6-bottle package has the lowest price per bottle, but it covers 180 days, so only the first half is protected by the refund.
Get It Today✓ 90-Day Money Back Guarantee ✓ Doses on the label
7.6
Out of 10
WORTH CONSIDERINGThe most common questions, from how to take it to how the refund works.
Yes. It is a real product with a published label, made by Advanced Bionutritionals and sold through Digistore24, a large and established online reseller. Your payment, support and refund go through them.
There is no published trial on this formula. One ingredient, CoQ10, has human trials showing a small to moderate drop in fatigue. For others, the studied doses are higher than what is in a serving. Results vary, which is why the 90-day guarantee matters.
Take 2 capsules a day, as the maker directs. Do not take more than the recommended amount.
The maker says some people feel less fatigue in the first weeks and suggests at least 3 months. Most supplement studies run 8 to 12 weeks, so give it that long before you judge it.
No caffeine or other stimulant is listed on the label.
The maker lists none. Niacin-type vitamins can cause stomach upset at high intakes, and the niacinamide dose here is above the 35 mg upper limit for supplemental niacin. If you take medication or have liver problems, ask your doctor first.
200 mg is 1,250% of the Daily Value and above the 35 mg upper limit that U.S. health agencies set for supplemental niacin. NIH reports liver effects at about 3,000 mg a day of nicotinamide, so this is far lower, but it is still a point to raise with your doctor.
The maker gives you 90 days from purchase. You return the bottles, even empty ones, and ask for a refund through support. The sales page mentions both paying return shipping and a refund that includes shipping, so confirm the details with support before ordering.
The maker says it is not sold in stores. The official website is the only place that sells the real product with the 90-day guarantee.
Every package includes the 90-day money-back guarantee. The price per bottle drops as you order more.
Sample Option
30 Day Supply
$79.95 /bottle
TOTAL: $79.95
Shipping shown at checkout
Order Now
Most Popular
90 Day Supply
$71.65 /bottle
Save $24.90 vs. 3 single bottles
TOTAL: $214.95
FREE SHIPPING, per the maker
Order Now
Biggest Savings
180 Day Supply
$66.65 /bottle
Save $79.80 vs. 6 single bottles
TOTAL: $399.90
FREE SHIPPING, per the maker
Order Now
Prices in US dollars, checked in October 2026 on the official website. The final price is the one shown at checkout. Our pick for a fair trial is the 3-bottle package, because it matches the 90-day guarantee window.
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